{"id":5007,"date":"2020-05-06T14:15:11","date_gmt":"2020-05-06T12:15:11","guid":{"rendered":"https:\/\/irlab.se\/?p=5007"},"modified":"2020-09-07T17:10:14","modified_gmt":"2020-09-07T15:10:14","slug":"irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet","status":"publish","type":"post","link":"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/","title":{"rendered":"IRLAB:s kliniska l\u00e4kemedelskandidat mesdopetam publicerad i JPET"},"content":{"rendered":"

\u201dDe tv\u00e5 artiklarna som nu publiceras i JPET<\/em> bidrar till den v\u00e4xande m\u00e4ngd data som st\u00f6der mesdopetam som en v\u00e4ldigt lovande l\u00e4kemedelskandidat f\u00f6r behandling av b\u00e5de motoriska och psykiatriska komplikationer vid Parkinsons sjukdom. Studien bidrar dessutom till det \u00f6kande antalet vetenskapliga publikationer som visar p\u00e5 en betydelsefull roll f\u00f6r dopamin D3-receptorn som ett m\u00e5lprotein f\u00f6r l\u00e4kemedel vid Parkinsons sjukdom\u201d, s\u00e4ger Susanna Waters, l\u00e4kare och medicine doktor, Director of Biology & Biostatistics p\u00e5 IRLAB.<\/p>\n

JPET, The Journal of Pharmacology and Experimental Therapeutics, <\/em>\u00e4r en h\u00f6gt rankad internationell tidskrift inom forskning kring farmakologi. Tidskriften \u00e4r utgiven av The American Society for Pharmacology and Experimental Therapeutics.<\/p>\n

Mesdopetam \u00e4r en l\u00e4kemedelskandidat i klinisk Fas II som utvecklas av IRLAB Therapeutics f\u00f6r behandling av levodopa inducerade dyskinesier vid Parkinsons sjukdom (PD-LIDs) och psykoser vid Parkinsons sjukdom (PD-P).<\/p>\n

Artikeln som rapporterar den prekliniska farmakologin visar att mesdopetam \u00e4r aktiv i modeller f\u00f6r levodopa-inducerade dyskinesier (LIDs) och i modeller f\u00f6r psykos. Denna effektprofil tillskrivs mesdopetams antagonism av dopamin D3-receptorer, med st\u00f6d av in vitro-studier och molekyl\u00e4ra modelleringsresultat.<\/p>\n

Artikeln av forskare vid Centrum f\u00f6r Molekyl\u00e4r Medicin (CMM), Institutionen f\u00f6r klinisk neurovetenskap p\u00e5 Karolinska Institutet, rapporterar om effekterna av mesdopetam p\u00e5 proteinniv\u00e5er och fosforylering. Slutsatsen \u00e4r att mesdopetam kan ha positiva effekter p\u00e5 nervcellsproteiner av betydelse f\u00f6r synaptisk plasiticitet och nervcellsignalering.<\/p>\n

De tv\u00e5 artiklarna publicerades online som en del av JPET Fast Forward<\/em>, vilken inneh\u00e5ller artiklar i manuskriptform som har accepterats och publicerats i JPET<\/em> men som inte har redigerats och inte har tilldelats ett nummer av tidskriften. Redigering, inklusive grafik, kan leda till vissa skillnader mellan Fast Forward-versionen och den slutliga versionen.<\/p>\n

Artikeln: Waters,\u00a0S. et al.<\/em> Preclinical pharmacology of [2-(3-fluoro-5-methanesulfonylphenoxy)ethyl](propyl)amine (IRL790), a novel dopamine transmission modulator for the treatment of motor and psychiatric complications in Parkinson\u2019s disease. Journal of Pharmacology and Experimental Therapeutics<\/em>, DOI:\u00a0https:\/\/doi.org\/10.1124\/jpet.119.264226<\/a><\/p>\n

Artikeln: Becanovic, K. et al. Effects of a novel psychomotor stabilizer, IRL790, on biochemical measures of synaptic markers and neurotransmission. Journal of Pharmacology and Experimental Therapeutics<\/em> DOI: https:\/\/doi.org\/10.1124\/jpet.119.264754<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

IRLAB meddelade idag att en vetenskaplig artikel som beskriver den prekliniska farmakologin f\u00f6r mesdopetam (IRL790), en dopamin D3-receptorantagonist f\u00f6r behandling av motoriska och psykiatriska symtom vid Parkinsons sjukdom har publicerats i The Journal of Pharmacology and Experimental Therapeutics, JPET. Dessutom publicerades ytterligare en artikel i JPET som indikerar att mesdopetam kan ha gynnsamma effekter p\u00e5 neurotrofiska faktorer som \u00e4r viktiga f\u00f6r bevarad synaptisk funktion och nervcellsignalering.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[23],"tags":[],"class_list":["post-5007","post","type-post","status-publish","format-standard","hentry","category-pressmeddelande-2"],"acf":[],"yoast_head":"\nIRLAB:s kliniska l\u00e4kemedelskandidat mesdopetam publicerad i JPET - IRLAB<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IRLAB:s kliniska l\u00e4kemedelskandidat mesdopetam publicerad i JPET - IRLAB\" \/>\n<meta property=\"og:description\" content=\"IRLAB meddelade idag att en vetenskaplig artikel som beskriver den prekliniska farmakologin f\u00f6r mesdopetam (IRL790), en dopamin D3-receptorantagonist f\u00f6r behandling av motoriska och psykiatriska symtom vid Parkinsons sjukdom har publicerats i The Journal of Pharmacology and Experimental Therapeutics, JPET. Dessutom publicerades ytterligare en artikel i JPET som indikerar att mesdopetam kan ha gynnsamma effekter p\u00e5 neurotrofiska faktorer som \u00e4r viktiga f\u00f6r bevarad synaptisk funktion och nervcellsignalering.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/\" \/>\n<meta property=\"og:site_name\" content=\"IRLAB\" \/>\n<meta property=\"article:published_time\" content=\"2020-05-06T12:15:11+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-09-07T15:10:14+00:00\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Skriven av\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Ber\u00e4knad l\u00e4stid\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuter\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/irlab.se\/#\/schema\/person\/f1a6ec2b5cf16bc3c6d2c8a3cc3b536d\"},\"headline\":\"IRLAB:s kliniska l\u00e4kemedelskandidat mesdopetam publicerad i JPET\",\"datePublished\":\"2020-05-06T12:15:11+00:00\",\"dateModified\":\"2020-09-07T15:10:14+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/\"},\"wordCount\":375,\"commentCount\":0,\"articleSection\":[\"Pressmeddelande\"],\"inLanguage\":\"sv-SE\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/\",\"url\":\"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/\",\"name\":\"IRLAB:s kliniska l\u00e4kemedelskandidat mesdopetam publicerad i JPET - IRLAB\",\"isPartOf\":{\"@id\":\"https:\/\/irlab.se\/#website\"},\"datePublished\":\"2020-05-06T12:15:11+00:00\",\"dateModified\":\"2020-09-07T15:10:14+00:00\",\"author\":{\"@id\":\"https:\/\/irlab.se\/#\/schema\/person\/f1a6ec2b5cf16bc3c6d2c8a3cc3b536d\"},\"breadcrumb\":{\"@id\":\"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/#breadcrumb\"},\"inLanguage\":\"sv-SE\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/irlab.se\/sv\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"IRLAB:s kliniska l\u00e4kemedelskandidat mesdopetam publicerad i JPET\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/irlab.se\/#website\",\"url\":\"https:\/\/irlab.se\/\",\"name\":\"Irlab\",\"description\":\"Novel treatments for Parkinson's disease\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/irlab.se\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"sv-SE\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/irlab.se\/#\/schema\/person\/f1a6ec2b5cf16bc3c6d2c8a3cc3b536d\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"sv-SE\",\"@id\":\"https:\/\/irlab.se\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/ca9ac6d5cafa1146003fcfd4a534f2590f937c279a5018bd860f6451bcacc0a5?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/ca9ac6d5cafa1146003fcfd4a534f2590f937c279a5018bd860f6451bcacc0a5?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"url\":\"https:\/\/irlab.se\/sv\/author\/irlab-user\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"IRLAB:s kliniska l\u00e4kemedelskandidat mesdopetam publicerad i JPET - IRLAB","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/","og_locale":"sv_SE","og_type":"article","og_title":"IRLAB:s kliniska l\u00e4kemedelskandidat mesdopetam publicerad i JPET - IRLAB","og_description":"IRLAB meddelade idag att en vetenskaplig artikel som beskriver den prekliniska farmakologin f\u00f6r mesdopetam (IRL790), en dopamin D3-receptorantagonist f\u00f6r behandling av motoriska och psykiatriska symtom vid Parkinsons sjukdom har publicerats i The Journal of Pharmacology and Experimental Therapeutics, JPET. Dessutom publicerades ytterligare en artikel i JPET som indikerar att mesdopetam kan ha gynnsamma effekter p\u00e5 neurotrofiska faktorer som \u00e4r viktiga f\u00f6r bevarad synaptisk funktion och nervcellsignalering.","og_url":"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/","og_site_name":"IRLAB","article_published_time":"2020-05-06T12:15:11+00:00","article_modified_time":"2020-09-07T15:10:14+00:00","author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Skriven av":"admin","Ber\u00e4knad l\u00e4stid":"2 minuter"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/#article","isPartOf":{"@id":"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/"},"author":{"name":"admin","@id":"https:\/\/irlab.se\/#\/schema\/person\/f1a6ec2b5cf16bc3c6d2c8a3cc3b536d"},"headline":"IRLAB:s kliniska l\u00e4kemedelskandidat mesdopetam publicerad i JPET","datePublished":"2020-05-06T12:15:11+00:00","dateModified":"2020-09-07T15:10:14+00:00","mainEntityOfPage":{"@id":"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/"},"wordCount":375,"commentCount":0,"articleSection":["Pressmeddelande"],"inLanguage":"sv-SE","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/","url":"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/","name":"IRLAB:s kliniska l\u00e4kemedelskandidat mesdopetam publicerad i JPET - IRLAB","isPartOf":{"@id":"https:\/\/irlab.se\/#website"},"datePublished":"2020-05-06T12:15:11+00:00","dateModified":"2020-09-07T15:10:14+00:00","author":{"@id":"https:\/\/irlab.se\/#\/schema\/person\/f1a6ec2b5cf16bc3c6d2c8a3cc3b536d"},"breadcrumb":{"@id":"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/#breadcrumb"},"inLanguage":"sv-SE","potentialAction":[{"@type":"ReadAction","target":["https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/irlab.se\/sv\/irlabs-kliniska-lakemedelskandidat-mesdopetam-publicerad-i-jpet\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/irlab.se\/sv\/"},{"@type":"ListItem","position":2,"name":"IRLAB:s kliniska l\u00e4kemedelskandidat mesdopetam publicerad i JPET"}]},{"@type":"WebSite","@id":"https:\/\/irlab.se\/#website","url":"https:\/\/irlab.se\/","name":"Irlab","description":"Novel treatments for Parkinson's disease","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/irlab.se\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"sv-SE"},{"@type":"Person","@id":"https:\/\/irlab.se\/#\/schema\/person\/f1a6ec2b5cf16bc3c6d2c8a3cc3b536d","name":"admin","image":{"@type":"ImageObject","inLanguage":"sv-SE","@id":"https:\/\/irlab.se\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/ca9ac6d5cafa1146003fcfd4a534f2590f937c279a5018bd860f6451bcacc0a5?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/ca9ac6d5cafa1146003fcfd4a534f2590f937c279a5018bd860f6451bcacc0a5?s=96&d=mm&r=g","caption":"admin"},"url":"https:\/\/irlab.se\/sv\/author\/irlab-user\/"}]}},"_links":{"self":[{"href":"https:\/\/irlab.se\/sv\/wp-json\/wp\/v2\/posts\/5007","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/irlab.se\/sv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/irlab.se\/sv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/irlab.se\/sv\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/irlab.se\/sv\/wp-json\/wp\/v2\/comments?post=5007"}],"version-history":[{"count":2,"href":"https:\/\/irlab.se\/sv\/wp-json\/wp\/v2\/posts\/5007\/revisions"}],"predecessor-version":[{"id":5009,"href":"https:\/\/irlab.se\/sv\/wp-json\/wp\/v2\/posts\/5007\/revisions\/5009"}],"wp:attachment":[{"href":"https:\/\/irlab.se\/sv\/wp-json\/wp\/v2\/media?parent=5007"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/irlab.se\/sv\/wp-json\/wp\/v2\/categories?post=5007"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/irlab.se\/sv\/wp-json\/wp\/v2\/tags?post=5007"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}